Safety and Immunogenicity of a Recombinant Adenovirus Type-5-Vectored Coronavirus Disease 2019 (COVID-19) Vaccine With a Homologous Prime-Boost Regimen in Healthy Participants Aged ≥6 Years: A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Trial6세 이상의 건강한 참가자를 대상으로 한 상동 프라임-부스트 요법을 사용한 재조합 아데노바이러스 5형 벡터 코로나바이러스 질병 2019(COVID-19) 백신의 안전성 및 면역원성: 무작위, 이중 맹검, 위약 대조, 2b상 시험Randomized Controlled Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] 임상, 진단, 치료기술, [키워드] Ad5-vectored COVID-19 vaccine Adenovirus adenovirus type-5-vectored COVID-19 vaccine Adults Adverse adverse events antibody Antibody Response boost children clinical Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine dose double-blind elicited ELISA enrolled enzyme enzyme-linked immunosorbent assay event geometric mean geometric mean titer geometric mean titers GMT GMTs healthy homologous homologous prime immune response immune responses immunogenicity increasing age MIN neutralizing antibody participant phase phase 2b trial. Placebo placebo-controlled trial prime-boost regimen pseudovirus neutralizing antibody Randomized RBD receiving Receptor binding domain recombinant recombinant adenovirus robust Safe Safety SARS-CoV-2 single dose tolerable Trial vaccination Vaccine Viral viral particle [DOI] 10.1093/cid/ciab845 PMC 바로가기 [Article Type] Randomized Controlled Trial
SARS-CoV-2 infection in cancer patients on active therapy after the booster dose of mRNA vaccinesmRNA 백신 추가 접종 후 활성 요법을 받는 암 환자의 SARS-CoV-2 감염Article Published on 2022-08-012022-09-11 Journal: European journal of cancer (Oxford, England : 1990 [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] active treatment anti-Spike IgG booster booster dose Booster vaccine cancer patient Cancer patients center Cohort COVID-19 Delta dose Follow-up geometric mean geometric mean titer geometric mean titers Health care Health care worker healthy subject healthy subjects indicate investigated Italy lowest malignancies median value microneutralization Microneutralization assay mRNA vaccine mRNA vaccines mRNA vaccines. Nasopharyngeal swab Neutralizing antibodies neutralizing antibody Occurrence occurrence of COVID-19 omicron Omicron variants outbreak Patient positive potential risk proportion protective role required SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants serological Siena solid malignancies solid malignancy solid tumor solid tumors tested the median the SARS-CoV-2 therapy Treatment tumors Type university Vaccine variants [DOI] 10.1016/j.ejca.2022.05.018 PMC 바로가기 [Article Type] Article
Immunogenicity and Reactogenicity of Ad26.COV2.S in Korean Adults: A Prospective Cohort Study한국 성인에서 Ad26.COV2.S의 면역원성과 반응성: 전향적 코호트 연구Article Published on 2022-07-112022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ad26 Ad26.COV2.S Adenovirus Adenovirus Vector Adverse adverse event adverse events AEs anti-S IgG Anti-spike baseline cellular immunity conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 decrease Delta Dilution enrolled enzyme enzyme-linked immunospot assay evaluated fatigue Fever followed by geometric mean geometric mean titers GMT GMTs GRADE Humoral immunity IgG antibody immunogenic immunogenicity injection site pain interferon interferon-γ Korean mononuclear cell MOST myalgia NAb titer Neutralizing Neutralizing activity neutralizing antibody responses omicron Omicron variant Omicron variants outcome pandemic participant Peripheral blood Prospective prospective cohort study resolved respiratory Safe SARS-CoV-2 serious AEs severe acute respiratory syndrome Coronavirus Single-dose South Korea T-cell immunity T-cell Response T-cell responses the median U/mL university hospital vaccination Vaccines. variant variants Viral Viral variants waning immunity wild-type WT SARS-CoV-2 [DOI] 10.3346/jkms.2022.37.e210 PMC 바로가기 [Article Type] Article
Neutralizing Activity Against SARS-CoV-2 Delta and Omicron Variants Following a Third BNT162b2 Booster Dose According to Three Homologous or Heterologous COVID-19 Vaccination Schedules3개의 동종 또는 이종 COVID-19 백신 접종 일정에 따라 세 번째 BNT162b2 추가 접종 후 SARS-CoV-2 델타 및 오미크론 변이체에 대한 중화 활성Article Published on 2022-07-112022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against applied baseline characteristics BNT BNT162b2 booster dose ChAd ChAdOx1 coronavirus COVID-19 cross-reactive Delta delta variant dose evaluated followed by geometric mean geometric mean titer geometric mean titers groups Heterologous highest homologous or heterologous include investigated neutralization test Neutralizing neutralizing activities Neutralizing activity Neutralizing antibodies neutralizing antibody not significantly different omicron Omicron variant Omicron variants participant plaque-reduction neutralization test PRNT respiratory robust SARS-CoV-2 schedule sera severe acute respiratory syndrome Coronavirus slight increase Spread tested vaccination Vaccine vaccine dose Vaccine-induced immunity vaccine. variant variants wild type [DOI] 10.3389/fcimb.2022.948014 PMC 바로가기 [Article Type] Article
Safety and Immunogenicity of an Inactivated COVID-19 Vaccine, WIBP-CorV, in Healthy Children: Interim Analysis of a Randomized, Double-Blind, Controlled, Phase 1/2 Trial건강한 어린이에서 비활성화된 COVID-19 백신 WIBP-CorV의 안전성 및 면역원성: 무작위, 이중 맹검, 대조, 1/2상 시험의 중간 분석Clinical Trial Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] adverse events Adverse reaction Adverse reactions age alum Antibody Response assigned children China clinical trial Cohort cohorts conducted Controlled COVID-19 COVID-19 vaccine detectable dose dose-escalation double-blind effective vaccine Effective vaccines elicited Escalation Fever followed by geometric mean geometric mean titer geometric mean titers grade 3 groups healthy children Humoral response immunogenicity inactivated Inactivated vaccine injection injection site pain Interim Intramuscular injection Mild neutralizing antibody participant phase Phase 1 phase 1 trial Phase 2 phase 2 trial Placebo placebo-controlled Randomized Randomly ranged Registered robust Safe Safety safety profile Safety. SARS-CoV-2 significantly higher tested three group three groups vaccination Vaccine [DOI] 10.3389/fimmu.2022.898151 PMC 바로가기 [Article Type] Clinical Trial
Antibody Responses to SARS-CoV-2 in Children With COVID-19COVID-19에 걸린 어린이의 SARS-CoV-2에 대한 항체 반응Article Published on 2022-06-222022-09-11 Journal: Journal of the Pediatric Infectious Diseases Socie [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed anti-S IgG anti-SARS-CoV-2 IgG Anti-spike antibody antibody level antibody levels Antibody Response Asymptomatic blood sample Blood samples caused children children with COVID-19 children. conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic Cutoff detectable effective evaluate feature geometric mean geometric mean titer geometric mean titers GMT GMTs highest humoral immune response humoral immune responses IgG immune responses immune system Infection longitudinal study neutralizing antibody peaked positive positive rate positive rates reached remained respiratory response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus South Korea symptom onset symptomatic Vaccine development were measured with COVID-19 [DOI] 10.1093/jpids/piac012 PMC 바로가기 [Article Type] Article
Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study네덜란드 의료 종사자의 4가지 다른 SARS-CoV-2 백신에 의해 유도된 SARS-CoV-2 변이체에 대한 항체 반응: 전향적 코호트 연구Article Published on 2022-05-172022-09-11 Journal: PLoS Medicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenovirus adenovirus vector-based vaccines adjusted age and sex Alpha Analysis Antibody Response Antibody titers AZD1222 Beta BNT162b2 booster booster vaccination cellular immunity COV2.S Delta Effectiveness Fold change followed by Gamma geometric geometric mean geometric mean titers GMT group groups head Head-to-head comparison Health care Health care worker highest include initial lack limitation linear mixed model Linear regression mRNA mRNA vaccine mRNA vaccines mRNA-1273 Netherlands neutralization neutralize Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers of BNT162b2 omicron Omicron variant performed prospective cohort prospective cohort study recipient recipients recognize reduction in SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera serum vaccination Vaccine variant VoC VOCs was performed was reduced wild-type [DOI] 10.1371/journal.pmed.1003991 PMC 바로가기 [Article Type] Article
Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccinationSARS-CoV-2에 대한 백신 유도 체액 반응은 급격히 감소했지만 세포 면역은 BNT162b2 백신 접종 후 6개월까지 유지되었을 가능성이 있습니다.Article Published on 2022-04-262022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] 50% neutralization titer 95% CI 95% confidence interval age alcohol alcohol consumption BNT162b2 Cell cell count Cell-mediated immunity cellular immunity completion coronavirus coronavirus disease coronavirus disease-2019 correlated declined dose elevated ELISPOT ELISpot assay evaluate evaluated Gender geometric mean geometric mean titer geometric mean titers healthy subject humoral IgG Immunoglobulin Immunoglobulin G interferon interferon-γ Interferon-γ releasing ELISpot assay median age neutralization neutralization titer neutralizing antibody of BNT162b2 parameter patients remained SARS-CoV-2 SARS-CoV-2 spike protein SFC Spike protein subjects vaccination vaccine-induced antibodies vaccine-induced antibody variant Variant of concern. [DOI] 10.1016/j.vaccine.2022.03.057 PMC 바로가기 [Article Type] Article
Evaluation of Immunogenicity by Pseudovirus Neutralization Assays for SARS-CoV-2 Variants after Primary and Booster Immunization1차 및 추가 접종 후 SARS-CoV-2 변이체에 대한 슈도바이러스 중화 분석에 의한 면역원성 평가Article Published on 2022-04-012022-09-11 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] baseline blood sample Blood samples booster booster dose collected COVID-19 COVID-19 vaccine determine disease dose Effectiveness enrolled evaluate Follow-up geometric mean geometric mean titer geometric mean titers GMT GMTs immune response immune responses immunization immunogenicity IMPROVE inactivated Inactivated COVID-19 vaccine instance NAb NAbs neutralization Neutralizing antibodies neutralizing antibody other variant other variants participant Participants peaked Primary and booster immunization Pseudovirus neutralization assay Pseudovirus neutralization assays reached Research SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 variants. second dose seroconversion rate seroconversion rates Spike protein status strain the spike protein the vaccine titers vaccination variant variants were measured within 6 months Wuhan Wuhan-Hu-1 [DOI] 10.1016/j.ijid.2022.01.068 PMC 바로가기 [Article Type] Article
BNT162b2 Third Booster Dose Significantly Increases the Humoral Response Assessed by Both RBD IgG and Neutralizing Antibodies in Renal Transplant RecipientsBNT162b2 3차 부스터 용량은 신장 이식 수혜자의 RBD IgG 및 중화 항체 모두에 의해 평가된 체액 반응을 상당히 증가시킵니다Article Published on 2022-03-212022-09-11 Journal: Transplant International [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% CI Allograft antibody Antibody Response BNT162b2 BNT162b2 vaccine booster COVID-19 COVID-19 vaccine develop Diabetic diabetic nephropathy Dilution domain dose effective ESRD geometric mean geometric mean titer geometric mean titers GMT GMTs group had no humoral Humoral response IgG Immunosuppression increase independent predictor independent predictors mycophenolic acid negative and positive nephropathy Neutralizing antibodies neutralizing antibody non-responder non-responders of BNT162b2 Patient positive predictor pseudo-virus RBD RBD IgG Receptor-binding domain recipient recipients remained renal Renal transplantation renal transplantation. Responder responders response response rate SARS-CoV-2 secondary to seroconverted significant increase stratified systemic systemic AEs the vaccine Transplant Vaccine were recorded [DOI] 10.3389/ti.2022.10239 PMC 바로가기 [Article Type] Article